Another Beyond CMOS Candidate

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H. J. De Los Santos is with NanoMEMS Research and they have proposed a new beyond CMOS computer architecture called Nano-electron-fluidic logic.

Theory of Nano-Electron-Fluidic Logic (NFL): A New Digital “Electronics” Concept

A new digital “electronics” concept is introduced. The concept, called nano-electron-fluidic logic (NFL), is based on the generation, propagation and manipulation of plasmons in a two-dimensional electron gas behaving as an electron fluid. NFL gates are projected to exhibit femtojoule power dissipations and femtosecond switching speeds at finite temperatures. NFL represents a paradigm shift in digital technology, and is poised as a strong candidate for “beyond- CMOS” digital logic.

* Operates with far less heat and more efficient energies (femtojoules)
* Faster switching speeds (femtosecond)
* higher density potential for devices
* Terahertz operating speeds for chips
* Propogation velocity of electron fluid is hundreds of times faster than electrons in current CMOS
* Device construction is compatible with current lithography

Nano-Electron Fluidic Logic (NFL) Device patent application 2009026764

A nano-electron fluidic logic (NFL) device for controlling launching and propagation of at least one surface plasma wave (SPW) is disclosed. The NFL device comprises a metallic gate patterned with a plurality of terminals at which SPWs may be launched and a plurality of drain terminals at which the SPWs may be detected. A wave guiding structure such as a 2 DEG EF facilitates propagation of the SPW within the structure so as to scatter/steer the SPW in a direction different from a pre-scattering direction. A bias SPW is excited by an application of a control SPW with a momentum vector at an angle to the bias SPW and a control current with a wavevector which scatters the bias SPW in the direction of at least one output SPW, towards a drain terminal. The NFL device being rendered with device speed as a function of SPW propagation velocity.

* speed of the device is a function of SPW propagation velocity in terahertz switching frequencies.

A previous paper from 2004 by Héctor J. De Los Santos: NanoMEMS SYSTEMS ON CHIP

NanoMEMS exploits the convergence between nanotechnology and microelectromechanical systems (MEMS) brought about by advances in the ability to fabricate nanometer-scale electronic and mechanical device structures. While the “nano” aspect of this field is in its infancy, and is not expected to reach maturity until well into the 21st century, its “MEMS” aspect is a topic of much current and near-term impact in, for instance, RF/Wireless communications. In this context, we discuss the fundamentals of NanoMEMS, in particular, as it relates to its most speculative and futuristic paradigms and applications, and then focus on the RF/Wireless MEMS aspect, specifically in its role as enabler of ubiquitous wireless connectivity.

 

 


Mars: The endless kvetch about life on Mars

Posted by: admin  :  Category: Physics

Here is a NOVA show : Is There Life on Mars?

After four decades of fly-by probes, orbiters, landers, and rovers, the quest for life on Mars is as tantalizing as ever. With unique access to the NASA Phoenix and Mars Exploration Rover missions, NOVA shows scientists and engineers in action, directing the operations of spacecraft millions of miles away, as the robotic explorers drill into rock, claw into soil, analyze samples, and trundle across the rock-strewn landscape in search for signs that Mars once or maybe even still harbors some form of life. NOVA goes behind the scenes of the latest NASA missions to the Red Planet to reveal new clues and challenges on the road to answering this ultimate question: Is there life on Mars? See some of the finest images ever taken of the martian surface—including Phoenix’s most famous—on the program’s companion website.

If it takes this long to figure out, maybe the answer is, no.

Like, how long would it take to figure out if there is life on Earth? Clue: Bacteria live at high altitudes and latitudes that few even notice. Here on the level ground we kill zillions of life forms every time we wash our hands or sterilize a piece of equipment. And no one cares because there are plenty more where they came from.

If a planet has life, you will know, pretty quickly.

Conventional Uranium Supply and Demand

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Niger Could Move Beyond Current Levels of Top Uranium Producing Nations

Niger to triple uranium production in the next few years Niger communication minister and government spokesman Mohamed Ben Omar has said his country plans to raise its annual uranium production from 3,500 to 10,500 tonnes a year in the next few years.

21 page presentation (from 2007) on Niger Uranium Limited.

100% of Niger’s Uranium Production kin 2006 came from Areva’s Somair and Cominack Mines near Arlit. A mere $10 million exploration program spread over 2 years just completed in 2009. The growth to 10,000 tons/year is coming from the meager spending on exploration.

At the beginning of 2009, Niger and the French state mining company agreed a deal to build near Arlit the Imouraren mine. Areva would hold a 66% stake to the Nigerien mining office’s 33%. At a projected output of five thousand tonnes of ore a year, it would be largest uranium mine in the world by 2012, as the SOMAIR and COMINAK mines are phased out. The deal would make Niger the second largest uranium producer in
the world, and included plans to construct a civil nuclear power station for Niger.

Niger has a substantial amount of political unrest but this unrest is not hindering exploitation or shipment of uranium.

Despite the violence in the Air Massif, Areva NC and the Nigerien government were by later 2008 unhindered in their exploitation of the Arlit uranium mines and in the transport of its product by highway to ports in Benin.

The Imouraren mine will le launched with an initial investment of more than 1.2 billion euros (1.6 billion dollars) and create almost 1,400 jobs. Once up to full production capacity, it should be producing 5,000 tonnes of uranium a year for 35 years.

Despite the unrest France, China, India and others are in Niger and cutting deals and getting Uranium. France seems to know how to get what they want out of Africa. It is like they have many decades of experience and the willingness to do whatever it takes to supply the nuclear reactors that provide 80% of France’s electricity.

Niger to award 100 exploration permits to ramp up uranium industry . Niger Energy and Mines Minister Mamadou Abdulahi said that the country will award 100 mining exploration permits over the next two years. State-controlled French utility Areva has enjoyed a monopoly on production of uranium in Niger for some 40 years. In recent years, the
government has issued a slew of new exploration licences in an effort to diversify the uranium sector. (Resource Investor Jan 10, 2008)

Kazakhstan Situation

Kazakhstan is a dictatorship. It appears to be a stable dictatorship. Kazatomprom, a state-owned holding company produces the uranium.

Former Kazatomprom head Mukhtar Dzhakishev and other company officials illegally shifted ownership of uranium mines worth tens of billions of dollars through a network of offshore companies, the KNB security
service said.

Interpretation: An underboss over-reached and got put down by the Godfather and the Don’s security forces. Or the whatever the real story is… the top
guy decide to put down one of his underlings. The uranium is real and the reserves look real too. The Godfather in the movie had an olive oil business that was “real”.

Just like the developed countries deal with bastards who control oil, they will deal with bastards who control uranium. The bastards with oil and uranium still sell it. It is not a question of if they will sell, it is a question of price.

Wikipedia has some info on the Kazakhstan dictatorship. The years following independence have been marked by significant reforms to the Soviet-style economy and political monopoly on power. Under Nursultan Nazarbayev, who initially came to power in 1989 as the head of the Communist Party of Kazakhstan and was eventually elected President in 1991, Kazakhstan has made significant progress toward
developing a market economy. The country has enjoyed significant economic growth since 2000, partly due to its large oil, gas, and mineral reserves. Democracy, however, has not gained much ground since 1991. “In June 2007, Kazakhstan’s parliament passed a law granting President Nursultan Nazarbayev lifetime powers and privileges, including access to future presidents, immunity from criminal prosecution, and influence over domestic and foreign policy. Critics say he has become a de facto “president for life.”

Kazakhstan’s National Security Committee (KNB) was established on June 13, 1992. It includes the Service of Internal Security, Military Counterintelligence, Border Guard, several Commando units, and Foreign Intelligence (Barlau). The latter is considered by many as the most important part of KNB. Its director is Major General Omirtai Bitimov.

Energy is the leading economic sector. Production of crude oil and natural gas condensate in Kazakhstan amounted to 51.2 million tons in 2003, which was 8.6% more than in 2002.

Canada Uranium Situation

The delays in bringing the Canadian mines into production are not insurmountable. Especially if supply issues were idling hundreds of billions of dollars in nuclear plants. $2-3 billion more to overcome the flooding would be made available. Just like tens of billions go to solve oil sand recovery. Higher uranium prices also would also justify the investment needed to fix the problems. Canada also continues to find 4000-7000 ppm deposits.

World Nuclear Association report on Canada’s Uranium

Canada’s production is expected to increase significantly after 2011 as several new mines, now planned or under construction, go into operation.

Uranium production in Canada is likely to increase significantly as several new mines, now planned or under construction, go into operation sometime after 2011. The two largest projects are Cameco’s Cigar Lake mine and Areva’s Midwest mine, both in northern Saskatchewan. The mill at McClean Lake has been modified to process ore from both mines. The Rabbit Lake mill will also be modified to take ore from Cigar Lake. Total production is expected to be 8,200 t/y U3O8 from Cigar Lake and 2,600 t/y from Midwest.

The proven and probable ore reserves at Cigar Lake are extremely large and very high grade. A 450-metre-deep underground mine is being developed in very poor ground conditions. Hence it will use ground freezing and high pressure water jets to excavate the ore. High-grade ore slurry from remote mining will be trucked for toll treatment at Areva’s expanded McClean Lake mill, 70 km northeast, for the first two years. The average feed grade will be 20.7% U3O8. Then, as production approaches full capacity, all of the leaching will be done at McClean Lake but about half of the uranium solution will go on to Cameco’s Rabbit Lake mill 70 km east for final production of uranium oxide concentrate. From both mills total production is expected to be 8,200 t/y U3O8 (7,000 tU/y) ramping up to this over three years from production start in 2011. Known resources are 160,000 tonnes U3O8 at about 19% average grade, and with other resources the mine is expected to have a life of at least 30 years.

Construction on the project began in 2005 with production originally scheduled to start in 2011. However, underground floods in 2006 and 2008 set the start date back until after 2011 and increased the overall cost of the project from C$660 to more than C$1billion. There will be extra requirements for pumping capacity and ground refrigeration. Some 1.3 million cubic metres of waste rock from Cigar Lake is being emplaced under water in the Sue C pit at McClean Lake, to prevent acid generation from it. Tailings will remain at Mclean Lake and Rabbit Lake.

A Cigar Lake II deposit nearby is being investigated.

In addition to mining operations planned for the near future, active exploration involving more than 40 companies continues in many parts of Canada. While exploration has concentrated on northern Saskatchewan, new prospects extend to Labrador and Nova Scotia in the Atlantic provinces, Nunavut Territory in the far north, Quebec province and Ontario’s Elliott Lake area. Resource figures quoted are generally NI 43-101 compliant.

In uranium-rich northern Saskatchewan, exploration projects are now well-advanced at three locations. The Millennium deposit (42% owned by Cameco, 30% by JCU and 28% Areva Resources) has indicated resources of 21,000 tonnes of 4.5% grade U3O8 and 4,400 tonnes of 2.1% grade inferred. Ore would be milled at Key Lake. A feasibility study on the project is under way. The Tamarack deposit associated with Dawn Lake is also a focus of interest.

The Shea Creek project (51% owned by Areva, 49% UEX Corp.) in the western Athabasca Basin has reported very high grade ore and a 900 metre shaft is being sunk to provide better access. UEX (21.3% owned by Cameco) has invested about C$30 million in exploration. UEX is also exploring the Horseshoe and Raven deposits at Hidden Bay in the eastern Athabasca basin (close to Rabbit Lake and McClean Lake). The Horseshoe deposit has indicated resources of 11,100 tonnes of U3O8 at a grade of 0.237%, and Raven has indicated resources of 7,060 tonnes at 0.02% cut-off.

Denison is actively exploring the Wheeler River deposit half way between Key Lake and McArthur River. It is a long strike from the latter and geologically very similar, with some high-grade uranium mineralisation.

The main Labrador prospect centres on the Michelin deposit, which is being drilled in a C$21million program by Aurora Energy Resources (46.8% Fronteer Development). Michelin and the adjacent Jacques Lake deposit have identified resources of 46,000 tonnes of U3O8. Michelin was originally scheduled for development starting in 2010, but a provincial government moratorium until 2011 will delay the project. In Nova Scotia, exploration has been proposed at Millet Brook, but it awaits a review of a 1985 moratorium on uranium mining in the province.

Far north in the Nunavut Territory, a joint venture headed by Areva is conducting a feasibility study on the Kiggavik uranium deposit in the Thelon Basin, with an estimated 67,000 tonnes U3O8 at 0.24% grade. The indigenous Inuit organization, Nunavut Tunngavic, reversed its previous ban on uranium exploration and mining in 2006, but the project has faced opposition from other groups. The project involves the development of three open pit mines at Kiggavik and both an open pit mine and an underground mine at Sissons. Areva and its partners, JCU (Canada) Exploration and Daewoo, hope for a start-up of the mine and mill complex in 2015.e

Also in Nunavut, at Amer Lake, Uranium North Resources has reported resources of 8,770 t U3O8.

In Quebec, exploration is underway at several locations with a total of more than 40,000 tonnes of indicated or inferred deposits. Strateco Resources has reported indicated resources of 1,700 t U3O8 grading 0.68% and inferred resources of 6,000 tonnes grading 0.44% at its Matoush deposit in the Otish Basin of central Quebec. The company completed a scoping study in 2008 and will begin underground development in mid-2009, with a view to mine production in 2012. Azimut Exploration has committed C$42 million to uranium exploration, mainly for the Katavic project in Quebec’s northern Nunavik region and other prospects in the Ungava Bay region further north. Uracan Resources reports 18,400 tonnes of U3O8 of inferred resources at its North Shore prospect in eastern Quebec.

The Elliot Lake area of Ontario, which was the centre of Canada’s early uranium mining, is again attracting exploration. In September 2008, Pele Mountain Resources commenced the permitting process for its Eco Ridge underground uranium mine and processing facility in the region. Eco Ridge contains indicated resources of 5,700 tonnes U3O8 and inferred resources of 37,300 tonnes U3O8.

In British Columbia, the Blizzard prospect south of Kelowna, which was first explored in the 1980s, has been revived by Boss Power. The company has challenged a provincial government moratorium on exploration and mining imposed in April 2008, and the British Columbia government has indicated the Blizzard project may be able to go forward.

Uranium exploration appears to be on the upswing throughout Canada. Cameco spent C$57 million on exploration in 2008 (plus a further $32 million in three strategic partnerships with junior explorers) and plans C$50-55 million for 2009, mainly in Saskatchewan, Nunavut and the Northwest Territories. In late 2007, Cameco announced an agreement with the Russian company Uranium Holding ARMZ (JSC Atomredmetzoloto)
to create a joint venture to explore and mine uranium in northwest Russia, Saskatchewan and Nanavut.

 
 


Mach Effect: Interview with Paul March and an Update on the Work of James Woodward

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The 2009 3rd generation shuttler device that is to be tested through the end of 2009 by James Woodward

Question “The reaction to the unidirectional force proven with the work you did in 2007?”

Actually the Mach-2MHz work was reported in my and Andrew Palfreyman’s STAIF-2006 paper and even though the unidirectional forces reported where above 1.0 milliNewton, in the eyes of the scientific community Woodward’s and my work is still considered “spurious noise” and nothing more. Paradigm changing takes a lot of effort and data…

Question “What is a near term achievable work that could be done in 5 years?”

It depends on the health of Jim Woodward and the time and resources I can to bring bear on my M-E work. I’m working full time on the NASA Project Orion electrical power system at JSC and until I get a break from that, I don’t have much time or energy to push the M-E wagon.

Question “What do you think of the EMdrive work?”

The proposed E&M/SRT conjecture IMO is garbage. The experimental results is tantalizing, but it has to be repeated in a vacuum chamber to get rid of possible spurious error sources for the thrust signatures observed. If it still moves in a 1×10-4 Torr vacuum, then we have to explain what is going on in view of Jim’s work.

EMDrive site

Question “Comment on other Lorentz force propulsion work”

This is conventional electric induction motor effect that is well understood in the current electrical sciences. My concern is over the possible maximum level of magnitude of this effect with realistic power supplies that a satellite can provide. In other words its merits have yet to be proven, to me at least.

Question “What is useful background information to understand this work?”

Dr. Woodward’s California State University web page which has an excellent write up on his M-E conjecture. See: http://physics.fullerton.edu/Woodward.html and first check out his “Gravitation” page and his “Origins of Inertia” essays.

“How much budget is needed for the third generation shuttler device ? Is that in hand ?”

Dr. Woodward has already fabricated the third gen parts, see attached picture, and he just needs a few weeks in his Fullerton lab to assemble them and then install the new test article in his ARC-Lite torque pendulum/vacuum chamber test rig before testing starts.

Question “How long will it take to test it ?”

Once debugged, the initial results should be evident within a week’s worth of trial runs, but it’s the debugging time that can vary all over the lot depending on whether the Lab gods are for you or against you that week. I’d guess that if Jim stays healthy he could have it done by Thanksgiving if not before.

Question “If that worked what would the next steps be for fourth or fifth generation device ?”

That’s up to Jim, but you need to keep in mind that Dr. Woodward is retired and fighting lung cancer that was in remission the last time I asked him.

Question “Is it the high-k that is the more difficult characteristic or the / low mechanical fatigue dielectric (e-r> 1,000) or the magnetic permeability greater than 10 and preferably 100.”

All of the above. The stored energy in a cap for a given applied voltage is proportional to the capacitance & therefore the relative dielectric constant of the dielectric so higher k is better. As to fatigue, we have found these high-k ceramic dielectric as exemplified by the Vishay/Cera-Mite Y5U, (e-r=~5,000), barium titanate ceramic blend’s expression of the M-E mass fluctuation signal fades with constant usage, but returns to near normal after a rest period of days or when it is heated above its Curie temperature for a few hours. For a reliable thruster system we would have to find a least one way to extend this “fatigue” lifetime so it occurs over tens of thousands of hours instead of minutes of operating time. The large magnetic permeability is required to make the vxB toroidal magnetic circuit in the MLT much stronger so the rectified force output can be increased by the same desired permeability factor of 10 to 100 for a given mass fluctuation figure over the current dismal performance of the Y5U dielectric that has a magnetic permeability of 1.0. Lastly since the electrostrictive effect in the high-k caps subtracts from the M-E signal until the M-E signal simply neutralizes it, finding a high-k, but low electrostrictive constant material would be ideal. So the optimum dielectric for MLTs would therefore be a material with a dielectric constant of say ~10,000, a magnetic permeability of ~100, an electrostrictive constant at least two orders of magnitude down from the current electrostrictive constant of barium titanate, and a half thrust fatigue lifetime of say 100,000 hours. The only outfit that has ever played this game is I think MuRata and they were using it for EMI filters for printed circuits. DARPA and others R&D houses are primarily pushing high energy density caps, which simultaneously optimizes the k and voltage handling capabilities of the caps which is good thing for MLT caps, but they are not sufficient. When we can get some folks optimizing dielectric blends that can meet our above requirements is when useable 10,000+ Newton MLTs will start to become a reality.

Question “Is there some other question that you would like to provide the answer to or highlight so that someone reading this would take away an important insight ?”

Not at the moment but you or any other interested parties in the M-E need to read everything at Jim W.’s web site and some of his Foundations of Physics and STAIF papers including his seminal 2004 Origins of Inertia paper that is attached. After you’ve waded through all that you might also check out Denis Sciama’s 1953 Origins of inertia papers, which Jim W. bases his work on. Let me warn you though there is still several loose ends surrounding Woodward’s & Sciama’s work and they rest primarily around how is inertial reaction force’s momentum and energy conveyed effectively instantaneously between the distant mass in the universe to the locally accelerated mass Jim’s take on this question is that it has to be via radiation reaction forces conveyed by forward and backwards in time momenergy fluxes in the universe’s ambient gravity field that gives rise to inertial effects in universes that salute Mach’s principle. However there might also be another complimentary explanation and that is we actually do live in a hyperdimensional realm where gravitational momentum and energy AKA momenergy propagate thru higher dimensions as exemplified by String Theory’s 11 dimensional Brane Multiverse.

That’s all for now and have a great day.

RESEARCH ON LORENTZ FORCE PROPULSION AND ANOTHER PROPELLANTLESS ATTEMPT

Successful lorentz force propulsion experiment

Nextbigfuture proposal that lorentz force propulsion could accelerate fuel to a nuclear pulse propulsion space ship.

The Frontiers of Propulsion Science book has a chapter related to the Mach Effect work. There was also a study in the NASA Breakthrough Propulsion Projects.

 
 


SENS4 : Antiaging conference coverage

Posted by: admin  :  Category: Technology

Ouroboros has coverage of the SENS4: Antiaging conference.

The SENS site has all of the conference abstracts

UPDATE: SENS4, Session 6: Eliminating recalcitrant intracellular molecules: other

Claude Wischik spoke about preventing aggregation of tau protein, which is implicated in Alzheimer’s disease. Clinical trials of their aggregation-inhibiting drug Rember are promising.

Andrei Seluanov talked about naked mole rats, those odd-looking miracle rodents that live for 30 years and don’t seem to ever get cancer. Mole rat contact inhibition/cancer resistance was controlled by p53 and pRB, both known tumour suppressors.

Alex Whitworth spoke about the relationship between mitochondrial degradation and Parkinson’s disease genes [Parkin and PINK1 genes].

SENS4, Sessions 9 and 10: Rejuvenating extracellular material

Mark Pepys talked about treating amyloidosis by targeting serum amyloid P component (SAP), which is present in all amyloid deposits and plays a role in stabilizing them. Several years ago, Pepys discovered a compound (CPHPC) that quickly removes SAP from the bloodstream and from most amyloid plaques; however, clinical trials showed that CPHPC alone does not help people with advanced disease. Today, Pepys reported on some very promising results from combining CPHPC with an antibody, effectively targeting the antibody to amyloid: in mouse studies, plaques completely disappear. Clinical testing of this combination approach will begin in 2011.

Kendall Houk gave a very interesting talk on computationally designing enzymes from scratch. They plan to apply their recently published protocol to develop enzymes that can reverse the formation of Advanced Glycation End-products (AGEs) – sugar-modified proteins that accumulate with age and are implicated in several age-related diseases.

END UPDATE

Session 5: Eliminating recalcitrant intracellular molecules: the lysosome

Jeffrey Grubb spoke about new methods for delivering missing enzymes to the lysozomes of patients suffering from lysosomal storage diseases. Several of these should be able to deliver any protein to the lysozome, including novel ones capable of degrading undesirable intracellular molecules that accumulate with age and that normal lysosomes can’t handle. Central goal of the LysoSENS project

Ana Maria Cuervo spoke about the relationship between autophagy and aging. Artifically maintaining autophagy shows improved liver function in mice.

John Schloendorn discussed ongoing work at the SENS Foundation Research Center to develop new enzymes that can degrade harmful intracellular junk that accumulates with age. So far, they have discovered enzymes that can degrade A2E and 7-ketocholesterol, which are implicated in macular degeneration and osteoporosis, respectively. Their next step will be to construct a drug delivery system to get these enzymes to lysozomes, possibly using methods similar to those of Jeffrey Grub.

SENS4, Session 4: Adult regenerative capacity

Brandon Reines presented a counterintuitive result on regeneration: sometimes old animals have a higher regenerative capacity than young animals. In particular, if you punch a hole in the ear of a young mouse, then it won’t heal; but in a middle-aged mouse it will heal completely. He argued that this happens because mouse ear connective tissues never fully differentiate, and suggested that other neural-crest-derived connective tissues might show similar properties.

Kaisa Selesniemi talked about possible methods for sustaining fertility in older women. They found that an infusion of bone marrow from younger females keeps older mice fertile longer. They hope that these treatments might not only prolong fertility, but also female health: mice with longer “ovarian lifespan” show reduced disease incidence.

Alexandra Stolzing presented a new method for generating induced pluripotent stem cells (i.e., for reprogramming adult somatic cells to become pluripotent) that doesn’t use viral compounds or plasmids. Viruses can cause abnormalities in the reprogrammed cells, so much recent work has focused on developing alternate methods for deriving iPS cells

.

SENS4, Session 3: Optimising metabolism against aging

Stephen Spindler described his (ongoing) project to screen a large number of potential lifespan-affecting compounds in mice – so far, several candidates look promising. Interestingly, he also argued that the majority of previous studies measuring the effects of various compounds on rodent life expectancy suffer from serious flaws. In particular, he argued that many of them were confounded by a possible calorie restriction effect.

Manuel Serrano talked about his recent experiments with sirtuins in mice. Overexpression of sirtuins in yeast, worms, and flies delays aging, but their role in mammalian aging is still highly controversial. He found that mice overexpressing Sirt1 had improved health, according to several metrics – but no difference in lifespan.

David Melzer talked about his analyses of human genetic association studies. A large number of single nucleotide polymorphisms (SNPs) have been associated with age-related diseases in humans; Melzer showed that many of these are near genes that play a role in pathways relevant to aging, and also identified three genes associated with two or more age-related diseases: p16/p15, MYC, and TERT.

SENS4, Session 1: Combating oxidation

Vladimir Skulachev spoke about his extensive work with SkQ1, an antioxidant targeted to mitochondria. He reported that SkQ1 supplementation extends median lifespan in several species (including mammals), and slows the development of multiple age-related diseases and conditions.

Holly Brown-Borg talked about the connections between stress resistance and longevity in Ames dwarf mice, which live around 50% longer than normal mice and show elevated levels of some antioxidants.

Cathy Clarke tested an original and interesting approach to avoiding free radical damage to poly-unsaturated fatty acids, or PUFAs: isotope reinforcement. The basic idea here, explained in an earlier paper, is very simple: heavier isotopes make stronger bonds, so isotope-reinforced PUFAs will be more resistant to free radical attack. Will these results transfer to higher organisms? Is there any chance that the deuterium could get incorporated into other molecules, stabilizing proteins that we want to degrade? The authors plan to follow up this study in worms and mice.